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JoVE Journal Cancer Research
Flerdimensionale Coculture System til Model Lung Planocellualt Karcinom Progression
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Flerdimensionale Coculture System til Model Lung Planocellualt Karcinom Progression

Article DOI: 10.3791/60644-v • 07:53 min • March 17th, 2020
March 17th, 2020 •
1, 1, 1, 1
1Oncology R&D group, Pfizer Worldwide Research and Development

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En in vitro model system blev udviklet til at fange væv arkitektoniske ændringer under lunge planocelluøs karcinom (LUSC) progression i en 3-dimensionel (3D) co-kultur med kræft-associerede fibroblaster (CAFs). Dette organoid system giver en unik platform til at undersøge rollerne af forskellige tumor celle-iboende og ydre ændringer, der modulerer tumor fænotype.

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Kræft forskning 3D coculture lungekræft kræft-associerede fibroblaster acinar morfogenese tumor organoids
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