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含脂脂的微流体生产-温度敏感脂质体
JoVE Journal
Bioengineering
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JoVE Journal
Bioengineering
Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes
Please note that all translations are automatically generated.
Click here for the English version.
含脂脂的微流体生产-温度敏感脂质体
DOI:
10.3791/60907-v
•
09:51 min
•
March 03, 2020
•
Calvin C. L. Cheung
,
Guanglong Ma
,
Amalia Ruiz
,
Wafa T. Al-Jamal
1
School of Pharmacy
,
Queen’s University Belfast
Chapters
00:05
Introduction
01:06
Equipment Setup
02:46
Lysolipid-Containing Temperature-Sensitive Liposome (LTSL) Preparation
04:48
Remote Doxorubicin (DOX) Loading
05:48
Laser Heating and Triggered Release
07:13
Results: Representative LTSL10 Characterization, Loading, and Photothermal Heat Triggering
08:59
Conclusion
Summary
Automatic Translation
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Automatic Translation
该协议提出了使用交错的刺骨微流体器装置制备热敏脂质体的优化参数。这还允许将多索鲁比辛和丁氨酸绿色共同封装到脂质体中,并产生光热触发的多索鲁比素释放,用于控制/触发药物释放。
Tags
Microfluidics
Liposomes
Temperature-sensitive Liposomes
Drug Delivery
Doxorubicin
Indocyanine Green
Syringe Pumps
Micromixer
Lipid Mixture
Ammonium Sulfate
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