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A Screening Method for Identification of Heterochromatin-Promoting Drugs Using Drosophila
JoVE Journal
Genetics
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JoVE Journal Genetics
A Screening Method for Identification of Heterochromatin-Promoting Drugs Using Drosophila
DOI:

06:22 min

March 12, 2020

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Chapters

  • 00:05Introduction
  • 01:29Heterochromatin-Promoting Drug Screening
  • 02:55Eye Color Change Scoring
  • 04:31Results: Representative Drug Screening in Drosophila
  • 05:33Conclusion

Summary

Automatic Translation

Drosophila is a widely used experimental model suitable for screening drugs with potential applications for cancer therapy. Here, we describe the use of Drosophila variegated eye color phenotypes as a method for screening small-molecule compounds that promote heterochromatin formation.

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