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Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
DOI:

08:55 min

April 24, 2020

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Chapters

  • 00:05Introduction
  • 00:44Translaminar Autonomous System (TAS) Setup
  • 01:42Human Whole Eye Globe Preparation
  • 02:24IOP (Bottom) Chamber Setup
  • 03:20ICP (Top) Chamber Setup
  • 03:52Data Recording System Setup
  • 06:56Results: Representative Translaminar Autonomous System Model Analyses
  • 08:26Conclusion

Summary

Automatic Translation

We describe and detail the use of the translaminar autonomous system. This system utilizes the human posterior segment to independently regulate the pressure inside the segment (intraocular) and surrounding the optic nerve (intracranial) to generate a translaminar pressure gradient that mimics features of glaucomatous optic neuropathy.

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