Journal
/
/
量化秀丽隐杆线虫中组织特异性蛋白静剂下降
JoVE Journal
Biology
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Biology
Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
DOI:

09:18 min

September 07, 2021

, ,

Chapters

  • 00:04Introduction
  • 01:09Reagent Preparation
  • 02:19Synchronization and Inhibiting Progeny Production
  • 04:05Measuring Decline in Proteostasis
  • 06:39Results: HPK-1 Promotes Proteostasis
  • 08:37Conclusion

Summary

Automatic Translation

蛋白质静力学下降是衰老的标志,促进神经退行性疾病的发作。我们概述了一种方案,通过融合到荧光报告基因的多谷氨酰胺重复序列的异源表达来量化两种不同 秀丽隐杆线虫 组织中的蛋白质稳态。该模型允许对蛋白质稳态进行快速体内遗传分析。

Related Videos

Read Article