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Kvantificering af vævsspecifik proteostatisk tilbagegang i caenorhabditis eleganer
 
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Kvantificering af vævsspecifik proteostatisk tilbagegang i caenorhabditis eleganer

Article DOI: 10.3791/61100-v 09:18 min September 7th, 2021
September 7th, 2021

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Summary

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Proteostatisk tilbagegang er kendetegnende for aldring, der letter starten af neurodegenerative sygdomme. Vi skitserer en protokol til kvantificerbart måle proteostase i to forskellige Caenorhabditis elegans væv gennem heterologe udtryk for polyglutamin gentagelser smeltet til en fluorescerende reporter. Denne model giver mulighed for hurtig in vivo genetisk analyse af proteostase.

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Biologi proteostase polyglutamin polyQ::YPC C. elegans aldring biomarkør protein homøostase genetisk analyse funktionel genomforskning
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