This protocol describes the use of silicon nanowires for intracellular optical bio-modulation of cell in a simple and easy to perform method. The technique is highly adaptable to diverse cell types and can be used for in vitro as well as in vivo applications.
Rotenberg, M. Y., Schaumann, E. N., Prominski, A., Tian, B. Silicon Nanowires and Optical Stimulation for Investigations of Intra- and Intercellular Electrical Coupling. J. Vis. Exp. (167), e61581, doi:10.3791/61581 (2021).