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Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination
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Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination

DOI:
10.3791/61593-v

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05:39 min

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February 09, 2021

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, , , , ,
1Respiratory Medicine,Nagoya University Graduate School of Medicine, 2Nagoya University Institute for Advanced Research, 3B3-Unit, Advanced Analytical and Diagnostic Imaging Center (AADIC)/Medical Engineering Unit (MEU),Nagoya University Institute for Advanced Research

Chapters

  • 00:05Introduction
  • 00:31Pleural Dissemination Model Generation
  • 01:44Bioluminescence (BLI) Measurement
  • 03:02Near-Infrared Photoimmunotherapy (NIR-PIT)
  • 04:08Results: Representative NIR-PIT Thoracic Mouse Tumor Treatment
  • 05:13Conclusion

Summary

Automatic Translation

Automatic Translation

Near-infrared photoimmunotherapy (NIR-PIT) is an emerging cancer therapeutic strategy that utilizes an antibody-photoabsorber (IR700Dye) conjugate and NIR light to destroy cancer cells. Here, we present a method to evaluate the antitumor effect of NIR-PIT in a mouse model of pleural disseminated lung cancer and malignant pleural mesothelioma using bioluminescence imaging.

Tags

Keywords: Near Infrared PhotoimmunotherapyPleural DisseminationMouse ModelBioluminescence ImagingD-luciferin690-nanometer LaserLight Dose

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