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渗透泵的植入和压力的诱导，以建立一个症状，药理学小鼠模型DYT/PARK-ATP1A3肌张
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
Implantation of Osmotic Pumps and Induction of Stress to Establish a Symptomatic, Pharmacological Mouse Model for DYT/PARK-ATP1A3 Dystonia
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渗透泵的植入和压力的诱导，以建立一个症状，药理学小鼠模型DYT/PARK-ATP1A3肌张

DOI:
10.3791/61635-v

•

10:41 min

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September 12, 2020

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, , ,
1Department of Neurology,University Hospital of Würzburg

Chapters

  • 00:00Introduction
  • 00:47Priming of Osmotic Pumps
  • 01:46Implantation of Brain Cannulas and Osmotic Pumps
  • 05:50Stress Paradigm
  • 07:39Characterization of the Phenotype: Rating Scales
  • 09:31Results
  • 10:05Conclusion

Summary

Automatic Translation

Automatic Translation

我们提供一种方案，通过将牙兰膜植入与渗透泵相连的基底神经和小脑，生成药理学 DYT/PARK-ATP1A3 肌张肌小鼠模型。我们描述了通过应用运动挑战来诱导肌张力障碍的运动，以及通过行为评分系统表型的表征。

Tags

Osmotic PumpsBrain CannulasPharmacological Mouse ModelDYT/PARK-ATP1A3 DystoniaMotor StressGene-environment InteractionsMovement DisordersStereotactic SurgeryBasal GangliaCerebellum

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