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Microelectrode Array Registrering af sinoatrial Node Fyring Sats for at identificere iboende hjerte pacemaking defekter i mus
JoVE Journal
Medicine
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JoVE Journal Medicine
Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice
DOI:

09:20 min

July 05, 2021

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Chapters

  • 00:04Introduction
  • 00:58Dissecting the Sinoatrial Node
  • 03:50Microelectrode Array System Preparation for Recording
  • 04:18Heart Tissue Placement on Microelectrode Array Grid
  • 05:03Data Acquisition
  • 06:10Analysis of Microelectrode Array Recordings for Sinoatrial Node Beat Frequency Measurement
  • 07:13Results: The Sinoatrial Node Beat Frequency Measurement
  • 08:41Conclusion

Summary

Automatic Translation

Denne protokol har til formål at beskrive en ny metode til måling af iboende hjertefyringshastighed ved hjælp af mikroelektrode array registrering af hele sinoatrial node væv til at identificere pacemaking defekter i mus. Farmakologiske agenser kan også indføres i denne metode for at undersøge deres virkninger på iboende pacemaking.

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