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JoVE Journal
Biology

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Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein
 

Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein

Article DOI: 10.3791/63405-v
March 16th, 2022

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Summary March 16th, 2022

The present protocol describes a single M213L mutation in Gja1 that retains full-length Connexin43 generation but prevents translation of the smaller GJA1-20k internally translated isoform.

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