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En stabilt etableret topunktsinjektion af lysophosphatidylcholin-induceret fokal demyeliniseringsmodel hos mus
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Neuroscience
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JoVE Journal Neuroscience
A Stably Established Two-Point Injection of Lysophosphatidylcholine-Induced Focal Demyelination Model in Mice

En stabilt etableret topunktsinjektion af lysophosphatidylcholin-induceret fokal demyeliniseringsmodel hos mus

DOI:
10.3791/64059-v

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04:55 min

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May 11, 2022

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, , , , ,
1Department of Neurology, Tongji Hospital, Tongji Medical College,Huazhong University of Science and Technology

Chapters

  • 00:05Introduction
  • 00:43Surgical Preparation and Surgical Procedure
  • 02:34Results: The Effects of Two-Point Injection of the LPC in Demyelination, Myelin Regeneration, and the Spatial Memory of Mice
  • 04:30Conclusion

Summary

Automatic Translation

Automatic Translation

Den nuværende protokol beskriver en topunktsinjektion af lysophosphatidylcholin via en stereotaksisk ramme for at generere en stabil og reproducerbar demyeliniseringsmodel hos mus.

Tags

Focal DemyelinationLysophosphatidylcholineCorpus CallosumStereotaxic InjectionMultiple SclerosisMouse ModelLuxol Fast BlueDMBPWhite Matter Lesions

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