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Hybridcelleanalysesystem til vurdering af strukturelle og kontraktile ændringer af humane iPSC-afledte kardiomyocytter til præklinisk hjerterisikovurdering
JoVE Journal
Bioengineering
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JoVE Journal Bioengineering
Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation
DOI:

08:03 min

October 20, 2022

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Chapters

  • 00:04Introduction
  • 00:53Plate Coating
  • 01:58Seeding of Human iPSC‐Derived Cardiomyocytes into Flexible 96‐Well Plates (Day 0)
  • 02:56Medium Exchange of Flexible 96‐Well Plates (Day 1)
  • 03:53Final Medium Exchange Before Compound Addition (Day 5–7)
  • 04:21Compound Addition and Data Recording (Day 5–7)
  • 05:47Results: Contractility Assessment, Base Impedance, and EFP Recordings of Human iPSC‐Derived Cardiomyocytes After Drug Treatment
  • 07:35Conclusion

Summary

Automatic Translation

Analysen af ændringer i kontraktil funktion og cellulær integritet af humane iPSC-afledte kardiomyocytter er af enorm betydning for udviklingen af ikke-kliniske lægemidler. Et hybrid 96-brønds celleanalysesystem adresserer begge parametre i realtid og fysiologisk for pålidelige, menneskerelevante resultater, der er nødvendige for en sikker overgang til kliniske stadier.

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