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Chapters
- 00:05Title
- 02:18Nephrectomy
- 04:30Ischemia Reperfusion
- 06:26Results: Acute Kidney Injury and Post Injury Fibrosis
- 08:28Conclusion
We describe models of moderate and severe ischemia-reperfusion-induced kidney injury in which the mice undergo unilateral renal pedicle clamping followed by simultaneous or delayed contralateral nephrectomy, respectively. These models consistently give rise to renal dysfunction and post-injury fibrosis, but injury severity and survival are dependent on mouse background, age and surgical equipment.
