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A Murine Model of Myocardial Ischemia-reperfusion Injury through Ligation of the Left Anterior Descending Artery
JoVE Journal
Medicine
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JoVE Journal Medicine
A Murine Model of Myocardial Ischemia-reperfusion Injury through Ligation of the Left Anterior Descending Artery
DOI:

11:07 min

April 10, 2014

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Chapters

  • 00:05Title
  • 01:56Endotracheal Intubation
  • 04:00Thoracotomy
  • 05:29Left Anterior Descending Coronary Artery (LAD) Ligation and Reperfusion
  • 08:59Results: Representative Analysis of Murine Myocardial Ischemia-Reperfusion Injury
  • 10:05Conclusion

Summary

Automatic Translation

We introduce a surgical method to induce experimental ischemia/reperfusion (I/R) injury to simulate myocardial infarction (MI) in mouse models that allows for more clarity in positioning of the ligation on the left anterior descending artery (LAD) to increase the reproducibility of MI experiments in mice.

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