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Transplantation of Pulmonary Valve Using a Mouse Model of Heterotopic Heart Transplantation
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JoVE Journal Medicine
Transplantation of Pulmonary Valve Using a Mouse Model of Heterotopic Heart Transplantation

Transplantation of Pulmonary Valve Using a Mouse Model of Heterotopic Heart Transplantation

DOI:
10.3791/51695-v

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10:56 min

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July 23, 2014

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, , , , , , , , , ,
1Tissue Engineering Program and Surgical Research,Nationwide Children’s Hospital, 2Cardiothoracic Surgery,Nationwide Children’s Hospital, 3Pediatric Surgery,Nationwide Children’s Hospital

Chapters

  • 00:05Title
  • 01:56Donor Pulmonary Valve and Heart Tissue Preparation
  • 03:45Heart Valve Transplantation and Heterotopic Heart Transplantation
  • 08:29Results: Representative Transplanted Heart Valve Data
  • 09:53Conclusion

Summary

Automatic Translation

Automatic Translation

In order to understand the cellular and molecular mechanisms underlying neotissue formation and stenosis development in tissue engineered heart valves, a murine model of heterotopic heart valve transplantation was developed. A pulmonary heart valve was transplanted to recipient using the heterotopic heart transplantation technique.

Tags

Pulmonary Valve TransplantationMouse ModelHeterotopic Heart TransplantationDecellularized ValvesValve ThickeningStenosisHigh Frequency UltrasoundPulsed Wave DopplerForward FlowRegurgitationTransgenic Mice

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