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Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice
JoVE Journal
Medicine
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JoVE Journal Medicine
Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice
DOI:

08:41 min

October 27, 2014

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Chapters

  • 00:05Title
  • 01:17Tool Preparation
  • 02:23Carotid Artery Isolation
  • 03:37Securing of Catheter and Initiation of Blood Flow
  • 06:22Infusion
  • 07:19Results: Representative Pacilitaxel Levels During Carotid and Jugular Infusions
  • 08:13Conclusion

Summary

Automatic Translation

This method was developed with the goal of delivering a steady drug solution via the carotid artery, to assess the pharmacokinetics of novel drugs in mouse models.

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