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Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice
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Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice

DOI:
10.3791/51917-v

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08:41 min

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October 27, 2014

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,
1Program in Developmental Therapeutics,Fox Chase Cancer Center

Chapters

  • 00:05Title
  • 01:17Tool Preparation
  • 02:23Carotid Artery Isolation
  • 03:37Securing of Catheter and Initiation of Blood Flow
  • 06:22Infusion
  • 07:19Results: Representative Pacilitaxel Levels During Carotid and Jugular Infusions
  • 08:13Conclusion

Summary

Automatic Translation

Automatic Translation

This method was developed with the goal of delivering a steady drug solution via the carotid artery, to assess the pharmacokinetics of novel drugs in mouse models.

Tags

Carotid Artery InfusionPharmacokineticsPharmacodynamicsTaxanesMiceDrug DeliveryPaclitaxelJugular Vein InfusionCatheterizationRetro-orbital Blood Sampling

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