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An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus
JoVE Journal
Biology
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JoVE Journal Biology
An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus
DOI:

09:53 min

August 25, 2017

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Chapters

  • 00:05Title
  • 01:09KSHV Stock Preparation
  • 03:15Transduction of Endothelial Cells with E6 and E7 Papillomavirus Genes
  • 05:41Infection of Transduced Endothelial Cells with KSHV
  • 07:38Results: Phenotypic Changes in KSHV-infected Endothelial Cells
  • 09:15Conclusion

Summary

Automatic Translation

Kaposi sarcoma (KS) is a tumor induced by infection with the oncogenic virus human herpesvirus-8/KS herpesvirus (HHV-8/KSHV). The endothelial cell culture model described here is uniquely suited for studying the mechanisms by which KSHV transforms host cells.

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