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A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
 

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Article DOI: 10.3791/55825-v 07:52 min November 7th, 2017
November 7th, 2017

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Summary

This manuscript provides a detailed two-step surgical procedure to perform mouse 5/6th partial nephrectomy (PNx) with pole ligation. Four weeks after surgery, in comparison with sham-operated mice, the PNx mice developed impaired renal function, anemia, cardiac hypertrophy, cardiac fibrosis, and decreased heart systolic and diastolic function.

Tags

Mouse Nephrectomy Uremic Cardiomyopathy Pole Ligation Survival Rate Chronic Kidney Disease Pathology Reproducible Animal Model Sedation Body Temperature Surgical Area Incision Muscle Tissue Left Kidney
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