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En mus 5/6th Nephrectomy modell som induserer eksperimentell uremisk kardiomyopati
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En mus 5/6th Nephrectomy modell som induserer eksperimentell uremisk kardiomyopati

Article DOI: 10.3791/55825-v • 07:52 min • November 7th, 2017
November 7th, 2017 •
*1, *2, 2, 1, 2, 1,2
1Marshall Institute for Interdisciplinary Research (MIIR), Marshall University, 2Department of Biomedical Sciences, Marshall University Joan C. Edwards School of Medicine
* These authors contributed equally

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Dette manuskriptet gir en detaljert totrinns kirurgisk prosedyre for å utføre musen 5/6th delvis nephrectomy (PNx) med pole hemorroider. Fire uker etter operasjonen med humbug-opererte mus, PNx musene utviklet svekket nyre-funksjon, anemi, hjerte-hypertrofi, hjerte fibrose og redusert hjertefunksjon systolisk og diastolisk.

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Biomedisinsk Engineering problemet 129 kronisk nyresykdom 5/6th delvis nephrectomy pole hemorroider uremisk kardiomyopati Na/K-ATPase signalering oksidativt stress.
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