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Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
JoVE Journal
Cancer Research
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JoVE Journal Cancer Research
Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
DOI:

08:57 min

October 05, 2017

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Chapters

  • 00:05Title
  • 01:20Biological Sample Preparation
  • 03:35HPLC Instrumentation and Operation Parameters
  • 04:50Analysis of Samples
  • 05:46Results: Drug Combination Delivery of Doxorubicin and Mitomycin C in Nanoparticles
  • 07:43Conclusion

Summary

Automatic Translation

This protocol describes an efficient and convenient analytical process of sample extraction and simultaneous determination of multiple drugs, doxorubicin (DOX), mitomycin C (MMC) and a cardio-toxic DOX metabolite, doxorubicinol (DOXol), in the biological samples from a preclinical breast tumor model treated with nanoparticle formulations of synergistic drug combination.

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