Journal
/
/
Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis (NASH) Resolution
JoVE Journal
Medicine
This content is Free Access.
JoVE Journal Medicine
Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis (NASH) Resolution
DOI:

04:14 min

April 16, 2019

, , ,

Chapters

  • 00:04Title
  • 00:46Liver Biopsy
  • 02:24Results: Representative Effects of the Non-alcoholic Steatohepatitis (NASH) Diet on Mouse Liver Inflammation and Steatosis
  • 03:48Conclusion

Summary

Automatic Translation

In clinical settings, a liver biopsy is used to assess stages of non-alcoholic steatohepatitis (steatosis, inflammation, hepatocyte ballooning, and fibrosis). Here, we illustrate a survivable liver biopsy in mice which can be used for histological analyses to enable assessment of therapeutic agents in a manner more aligned with clinical trials.

Related Videos

Read Article