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A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
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Cancer Research
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JoVE Journal Cancer Research
A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice

DOI:
10.3791/59358-v

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08:55 min

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April 17, 2019

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, , , ,
1Department of Nuclear Medicine,Netherlands Cancer Institute

Chapters

  • 00:04Title
  • 00:3168Ga-DOTATATE Labeling
  • 02:2768Ga-DOTATATE Quality Control
  • 05:4968Ga-DOTATATE Administration and Positron-Emission Tomography/Computed Tomography (PET/CT) Imaging
  • 07:24Results: Representative 68Ga-DOTATATE PET/CT Imaging
  • 08:25Conclusion

Summary

Automatic Translation

Automatic Translation

Well-differentiated neuroendocrine tumors overexpress somatostatin receptors which can be utilized for diagnostic imaging with the radiolabeled somatostatin analog 68Ga-DOTATATE. This protocol details the radiolabeling of 68Ga-DOTATATE, quality control, patient preparation, and subsequent PET/CT imaging. Radiation safety and time constrictions due to the short half-life of 68Ga are taken into account.

Tags

68Ga-DOTATATEPET/CT ImagingNeuroendocrine TumorsGallium-68 LabelingPeptide AnalogQuality ControlSynthesis Protocol

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