JoVE Journal
Neuroscience
Neuroscience
A subscription to JoVE is required to view this content.
Chapters
Summary
Elevated spinal fluid protein levels can either be the result of diffusion of plasma protein across an altered blood-brain barrier or intrathecal synthesis. An optimized testing protocol is presented in this article that helps to discriminate both cases and provides quantitative measurements of intrathecally synthesized proteins.