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Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation
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Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation

Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation

DOI:
10.3791/635-v

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18:08 min

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December 31, 2007

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1Department of Developmental Immunology,La Jolla Institute for Allergy and Immunology

Chapters

  • 00:00Introduction
  • 00:44Physiological Role of CD1
  • 04:52CD1d Tetramers
  • 06:57Use of CD1d Tetramers in the Lab
  • 08:46CD1d Tetramer Generation
  • 11:40Therapeutic Utility of NKT Cells
  • 14:43Mucosal Immunity
  • 16:13Future of Immunology

Summary

Automatic Translation

Automatic Translation

Natural Killer T cells (NKT) are critical determinants of the immune response to cancer, regulation of autioimmunity, clearance of infection, and the development of artheriosclerotic plaques. In this interview, Mitch Kronenberg discusses his laboratory's efforts to understand the mechanism through which NKT cells are activated by glycolipid antigens.

Tags

Glycolipid Antigen PresentationCD1dNKT Cell ActivationImmune ResponseCancer TherapyAutoimmune Disease RegulationInfectious Agent ClearanceArtheriosclerotic PlaquesGlycolipid-reactive T CellsCD1d Tetramer TechnologyTherapeutic AgentsClinical TrialsImmunology Field

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