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Journal / Medicine / Avvio del carcinoma metastatico della mammella…
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Avvio del carcinoma metastatico della mammella dalla Targeting del duttale con Adenovirus-Cre
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Avvio del carcinoma metastatico della mammella dalla Targeting del duttale con Adenovirus-Cre: A Novel modello di topo transgenico di cancro al seno

Article DOI: 10.3791/51171-v • 07:14 min • March 26th, 2014
March 26th, 2014 •
*1, *1, 1, 1, 1, 1, 1, 2, 3, 4,5,6, 1
1Tumor Microenvironment and Metastasis Program, Wistar Institute, 2Department of Pathology and Lab Medicine, Perelman School of Medicine, University of Pennsylvania, 3Department of Microbiology and Immunology and Department of Genetics, Geisel School of Medicine at Dartmouth, 4Division of Endocrine and Oncologic Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, 5Rena Rowan Breast Center, Abramson Cancer Center, University of Pennsylvania, 6Center for Advanced Medicine, University of Pennsylvania
* These authors contributed equally

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Attivazione di mutazioni latenti con adenovirus-Cre nei risultati mammarie sistema duttale in un carcinoma mammario metastatico clinicamente rilevante. Incorporazione di un promotore YFP consente di tenere traccia di cellule tumorali metastatiche distali. Questo modello è utile per studiare metastasi latente, immunità anti-tumorale, e per la progettazione di nuove immunoterapie per trattare il cancro al seno.

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Medicina topi transgenici il cancro al seno le metastasi l'iniezione intraduttale mutazioni latenti adenovirus-Cre
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