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Opretholdelse af menneskelig glioblastom cellulær mangfoldighed Ex vivo ved hjælp af tredimensionel organoidkultur
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Opretholdelse af menneskelig glioblastom cellulær mangfoldighed Ex vivo ved hjælp af tredimensionel organoidkultur

Article DOI: 10.3791/63745-v • 07:11 min • August 25th, 2022
August 25th, 2022 •
1, 2, 1, 2
1Department of Neurological Surgery, Cleveland Clinic, 2Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic

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Her beskriver vi en metode til at generere glioblastom (GBM) organoider fra primære patientprøver eller patientafledte cellekulturer og opretholde dem til modenhed. Disse GBM-organoider indeholder fænotypisk forskellige cellepopulationer og genskaber tumormikromiljøer ex vivo.

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Kræftforskning nummer 186
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