JoVE Journal

Cancer Research

JoVE Cancer Research includes experimental approaches and methods to understand, detect, treat, and prevent cancer.

1 2 3 4 5 6 7 8 9…13 › 298 VIDEO ARTICLES

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Iftekhar A. Showpnil^1,2, Kyle R. Miller¹, Cenny Taslim¹, Kathleen I. Pishas¹, Stephen L. Lessnick^1,3, Emily R. Theisen^1,4

¹Center for Childhood Cancer and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, ²Molecular, Cellular, and Developmental Biology Program, The Ohio State University, ³Division of Pediatric Hematology/Oncology/Blood & Marrow Transplant, The Ohio State University, ⁴Department of Pediatrics, The Ohio State University

JoVE 61564

Monitoring Cancer Cell Invasion and T-Cell Cytotoxicity in 3D Culture

Yuan-Na Lin¹, Apsra Nasir¹, Sharon Camacho¹, Deborah L. Berry¹, Marcel O. Schmidt¹, Gray W. Pearson¹, Anna T. Riegel¹, Anton Wellstein¹

¹Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University

JoVE 61392

Methods Collection

Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells

Jina Lee*^1,2, Joo-Eun Lee*³, Seil Kim^1,4,5, Dukjin Kang¹, Hee Min Yoo¹

¹Microbiological Analysis Team, Group for Biometrology, Korea Research Institute of Standards and Science (KRISS), ²College of Pharmacy, Chungnam National University (CNU), ³Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), ⁴Convergent Research Center for Emerging Virus Infection, Korea Research Institute of Chemical Technology (KRICT), ⁵Department of Bio-Analysis Science, University of Science & Technology (UST)

JoVE 61285

Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells

Kamila Maliszewska-Olejniczak¹, Agnieszka Dróżdż¹, Martyna Waluś¹, Michał Dorosz¹, Michał A. Gryziński¹

¹Nuclear Facilities Operations Department, National Centre for Nuclear Research, Sołtana 7, 05-400 Otwock, Poland

JoVE 61399

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Claudia Rengucci¹, Giulia De Maio¹, Maura Menghi², Francesca Benzi², Daniele Calistri¹

¹Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), ²Diatech Pharmacogenetics srl

JoVE 59426

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

Jennifer A. Geisler^1,2,3, Jonathan M. Spehar^1,2, Sarah A. Steck^1,2, Anna Bratasz^1,4, Reena Shakya¹, Kimerly Powell^1,4, Gina M. Sizemore^1,2

¹The Comprehensive Cancer Center, The Ohio State University, ²Department of Radiation Oncology, The Ohio State University, ³Department of Veterinary Biosciences, The Ohio State University, ⁴Davis Heart & Lung Research Institute, The Ohio State University

JoVE 61272

Methods Collection

Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells

Katie A Thies¹, Sue E Knoblaugh², Steven T Sizemore¹

¹Department of Radiation Oncology, Arthur G. James Comprehensive Cancer Center and Richard L. Solove Research Institute, The Ohio State University Medical Center, ²Department of Veterinary Biosciences, Comparative Pathology and Digital Imaging Shared Resource, The Ohio State University

JoVE 61270

Methods Collection

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Xiangdong Lv*^1,2,3, Lacey E. Dobrolecki*^1,2,3, Yao Ding^1,2,3, Jeffrey M. Rosen^1,2,3, Michael T. Lewis^1,2,3, Xi Chen^1,2,3

¹Department of Molecular and Cellular Biology, Baylor College of Medicine, ²Lester and Sue Smith Breast Center, Baylor College of Medicine, ³Dan L. Duncan Cancer Center, Baylor College of Medicine

JoVE 61173

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody

Gururaj Shivange*^1,2, Tanmoy Mondal*^1,2, Evan Lyerly^1,2, Jeremy Gatesman³, Jogender Tushir-Singh^1,2

¹Laboratory of Novel Biologics, University of Virginia School of Medicine, ²Department of Biochemistry and Molecular Genetics, UVA Cancer Center, University of Virginia School of Medicine, ³Center for Comparative Medicine, University of Virginia

JoVE 60727

An Automated Differential Nuclear Staining Assay for Accurate Determination of Mitocan Cytotoxicity

Jingqi Pei*¹, Svetlana B. Panina*¹, Natalia V. Kirienko¹

¹Department of BioSciences, Rice University

JoVE 61295

Combined Conditional Knockdown and Adapted Sphere Formation Assay to Study a Stemness-Associated Gene of Patient-derived Gastric Cancer Stem Cells

Jixian Xiong*¹, Yuting Li*¹, Xiangyu Tan*¹, Li Fu¹

¹Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, Department of Pharmacology and Shenzhen University International Cancer Center, Shenzhen University School of Medicine

JoVE 60799

In Vivo Targeting of Xenografted Human Cancer Cells with Functionalized Fluorescent Silica Nanoparticles in Zebrafish

Xiaodan Qin*¹, Fabrice F. J. Laroche*¹, Saquib Ahmed M. A. Peerzade², Andrew Lam¹, Igor Sokolov^2,3,4, Hui Feng¹

¹Departments of Pharmacology and Medicine, Section of Hematology and Medical Oncology, The Cancer Research Center, Boston University School of Medicine, ²Department of Biomedical Engineering, Tufts University, ³Department of Mechanical Engineering, Tufts University, ⁴Department of Physics, Tufts University

JoVE 61187

Measuring Real-time Drug Response in Organotypic Tumor Tissue Slices

Nao Nishida-Aoki¹, Andrew J. Bondesson^1,2, Taranjit S. Gujral^1,2,3

¹Division of Human Biology, Fred Hutchinson Cancer Research Center, ²Department of Molecular and Cellular Biology, University of Washington, ³Department of Pharmacology, University of Washington

JoVE 61036

Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells

Yuri Frosi, Siti Radhiah Ramlan, Christopher J. Brown

¹p53 Laboratory, Neuros/Immunos, A*STAR (Agency for Science, Technology and Research)

JoVE 60850

An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function

Neal K. Ramchandani¹, Kenneth A. Kesler¹, Jonathon D. Rogers¹, Nakul Valsangkar¹, Samatha M. Stokes¹, Shadia I. Jalal²

¹Department of Surgery, Division of Cardiothoracic, Indiana University Melvin and Bren Simon Cancer Center, ²Department of Medicine, Medical Oncology Division, Indiana University Melvin and Bren Simon Cancer Center

JoVE 59255

Drug Screening of Primary Patient Derived Tumor Xenografts in Zebrafish

Meghan G. Haney^1,2, L. Henry Moore¹, Jessica S. Blackburn^1,2

¹Department of Molecular and Cellular Biochemistry, University of Kentucky, ²Markey Cancer Center, University of Kentucky

JoVE 60996

A 3D Spheroid Model for Glioblastoma

Joris Guyon^1,2, Laetitia Andrique^1,2, Nadège Pujol^1,2, Gro Vatne Røsland^3,4, Gaelle Recher^1,5,6, Andreas Bikfalvi^1,2, Thomas Daubon^1,2,4

¹University Bordeaux, LAMC, ²INSERM U1029, University Bordeaux, ³Department of Biomedicine, University of Bergen, ⁴CNRS, IBGC UMR5095, ⁵LP2N, CNRS UMR 5298, IOA, ⁶Institut d'Optique Graduate School, IOA

JoVE 60998

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion

Giridhar Mudduluru¹, Neka Large¹, Taeju Park^1,2

¹Children's Mercy Research Institute, Children's Mercy Kansas City, ²Department of Pediatrics, University of Missouri Kansas City School of Medicine

JoVE 60997

Methods Collection

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Yuxuan Xiao¹, John M. Lamar¹

¹Department of Molecular & Cellular Physiology, Albany Medical College

JoVE 60582

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Robert Y. S. Cheng¹, Nimit L. Patel², Timothy Back¹, Debashree Basudhar¹, Veena Somasundaram¹, Joseph D. Kalen², David A. Wink¹, Lisa A. Ridnour¹

¹Molecular Mechanism Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, ²Small Animal Imaging Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc.

JoVE 60316

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

Shuang Chen¹, Andreas Giannakou¹, Jonathon Golas¹, Kenneth G. Geles¹

¹Oncology R&D group, Pfizer Worldwide Research and Development

JoVE 60644

Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry

Cinthia N. Cuero¹, Brenda Iduarte¹, Patricia Juárez¹

¹Biomedical Innovation Department, Center for Scientific Research and Higher Education at Ensenada

JoVE 59028

Rat Mammary Epithelial Cell Transplantation into the Interscapular White Fat Pad

Lauren B. Shunkwiler¹, Jill D. Haag², Michael N. Gould², Bart M. G. Smits¹

¹Department of Pathology and Laboratory Medicine, Medical University of South Carolina, ²Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison School of Medicine and Public Health

JoVE 60401

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Mafalda Laranjo*^1,2,3,4, Maria João Carvalho*^1,2,3,4,5,6, Beatriz Serambeque^1,2,3, André Alves^2,7, Carlos Miguel Marto^1,2,3,4,8, Isabel Silva⁹, Artur Paiva^3,9,10, Maria Filomena Botelho^1,2,3,4,8

¹Institute of Biophysics, Faculty of Medicine, University of Coimbra, ²Coimbra Institute for Clinical and Biomedical Research (iCBR), area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, ³CNC.IBILI/Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, ⁴Clinical Academic Center of Coimbra (CACC), ⁵Universitary Clinic of Gynecology, Faculty of Medicine, University of Coimbra, ⁶Gynecology A Service, Coimbra Hospital and Universitary Center, ⁷Institute of Pharmacology & Experimental Therapeutics, Faculty of Medicine, University of Coimbra, ⁸Institute of Experimental Pathology, Faculty of Medicine, University of Coimbra, ⁹Cytometry Operational Management Unit, Clinical Pathology Service, Coimbra Hospital and Universitary Center, ¹⁰Polytechnic Institute of Coimbra, ESTESC-Coimbra Health School, Laboratory Biomedical Sciences

JoVE 60022

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