JoVE Journal

Cancer Research

JoVE Cancer Research includes experimental approaches and methods to understand, detect, treat, and prevent cancer.

1 2 3 4 5…9 › 213 VIDEO ARTICLES

Assessing Cell Viability and Death in 3D Spheroid Cultures of Cancer Cells

Michala G. Rolver¹, Line O. Elingaard-Larsen¹, Stine F. Pedersen¹

¹Section for Cell Biology and Physiology, Department of Biology, Faculty of Science, University of Copenhagen

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Dan Han¹, Veronica Rodriguez-Bravo¹, Sudeh Izadmehr¹, Josep Domingo-Domenech¹, Carlos Cordon-Cardo¹

¹Department of Pathology, Icahn School of Medicine at Mount Sinai

Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry

Ami Maruyama^1,2, Kenjiro Kami³, Kazunori Sasaki³, Hajime Sato³, Yuzo Sato^1,2, Katsuya Tsuchihara⁴, Hideki Makinoshima^1,2,4

¹Shonai Regional Industry Promotion Center, ²Tsuruoka Metabolomics Laboratory, National Cancer Center, ³Human Metabolome Technologies, Inc, ⁴Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Erin R. Bonner^1,2, Karim Saoud¹, Sulgi Lee^1,2, Eshini Panditharatna³, Madhuri Kambhampati¹, Sabine Mueller^4,5, Javad Nazarian^1,2,5

¹Center for Genetic Medicine, Children's National Health System, ²Institute for Biomedical Sciences, The George Washington University School of Medicine and Health Sciences, ³Dana-Farber Cancer Institute, ⁴Department of Neurology, University of California San Francisco, ⁵DIPG Centre of Expertise Zurich, Universitats-Kinderspital Zurich

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Hyeongsun Moon*¹, Leanne R. Donahue*¹, Dahihm Kim¹, Luye An¹, Andrew C. White¹

¹Department of Biomedical Sciences, Cornell University

Modeling Breast Cancer via an Intraductal Injection of Cre-expressing Adenovirus into the Mouse Mammary Gland

Dongxi Xiang^1,2, Luwei Tao^1,2, Zhe Li^1,2

¹Division of Genetics, Department of Medicine, Brigham and Women's Hospital, ²Department of Medicine, Harvard Medical School

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy

Bayu Brahma¹, Rizky I. Putri², Lenny Sari², Ramadhan Karsono¹, Denni J. Purwanto¹, Walta Gautama¹, Bob Andinata¹, Samuel J Haryono¹

¹Department of Surgical Oncology, Dharmais Cancer Hospital, ²Department of Anatomical Pathology, Dharmais Cancer Hospital

Using Microarrays to Interrogate Microenvironmental Impact on Cellular Phenotypes in Cancer

Rebecca Smith¹, Kaylyn Devlin¹, David Kilburn¹, Sean Gross¹, Damir Sudar², Elmar Bucher¹, Michel Nederlof², Mark Dane¹, Joe W. Gray¹, Laura Heiser¹, James E. Korkola¹

¹Department of Biomedical Engineering, Knight Cancer Institute, Oregon Health and Science University, ²Quantitative Imaging Systems LLC

A Melanoma Patient-Derived Xenograft Model

Min Xiao¹, Vito W. Rebecca¹, Meenhard Herlyn¹

¹Wistar Institute

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Min-na Chen¹, De Zeng², Zhuo-qun Zheng³, Zheng Li³, Jian-le Wu³, Jun-yu Jin³, He-jia Wang³, Cui-zhen Huang¹, Hao-yu Lin¹

¹Department of Thyroid and Breast Surgery, First Affiliated Hospital of Shantou University Medical College, ²Department of Medical Oncology, Cancer Hospital of Shantou University Medical College, ³Shantou University Medical College

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment

Cinzia Donato*¹, Barbara M. Szczerba*¹, Manuel C. Scheidmann*¹, Francesc Castro-Giner^1,2, Nicola Aceto¹

¹Cancer Metastasis Laboratory, Department of Biomedicine, University of Basel and University Hospital Basel, ²SIB Swiss Institute of Bioinformatics

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

Anna Billeschou¹, Jenna Hunt¹, Hannelouise Kissow^1,2

¹Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, ²Novo Nordisk Foundation Center of Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

Ravan Moret¹, Linh Hellmers¹, Xin Zhang¹, Jessie Gills², Nathan Hite³, Aaron Klinger³, Grace A. Maresh¹, Daniel Canter^2,4, Stephen Bardot^2,4, David A Margolin^3,4, Li Li^1,4

¹Laboratory of Translational Cancer Research, Institute for Translational Research, Ochsner Clinic Foundation, ²Department of Urology, Ochsner Clinic Foundation, ³Department of Colon and Rectal Surgery, Ochsner Clinic Foundation, ⁴Ochsner Clinical School, University of Queensland, School of Medicine

Fully Human Tumor-based Matrix in Three-dimensional Spheroid Invasion Assay

Erika Naakka¹, Katja Tuomainen¹, Henrik Wistrand*¹, Miila Palkama*¹, Ilida Suleymanova¹, Ahmed Al-Samadi¹, Tuula Salo^1,2,3,4

¹Department of Oral and Maxillofacial Diseases, Clinicum, Faculty of Medicine, University of Helsinki, ²Cancer and Translational Medicine Research Unit, University of Oulu, ³Medical Research Center, Oulu University Horspital, ⁴Helsinki University Hospital

Droplet Digital TRAP (ddTRAP): Adaptation of the Telomere Repeat Amplification Protocol to Droplet Digital Polymerase Chain Reaction

Mohammed E. Sayed¹, Aaron L. Slusher¹, Andrew T. Ludlow¹

¹School of Kinesiology, University of Michigan

Longitudinal Intravital Imaging of Brain Tumor Cell Behavior in Response to an Invasive Surgical Biopsy

Maria Alieva¹, Anne C. Rios¹

¹Cancer Genomics Netherlands, Prinses Máxima Center for Pediatric Oncology

Digital Analysis of Immunostaining of ZW10 Interacting Protein in Human Lung Tissues

Yuan Wen¹, Xie Song-ping², Liu Pan³, Liu Xiao-yan¹, Pan Shan⁴, Yin Qian⁴, Sun Meng⁵, Huang Xiao-xing⁶, Xiao Rui-jing⁴, Xiong Jie⁴, Zhang Qiu-ping⁴, Shao Liang¹

¹Department of Hematology, Zhongnan Hospital of Wuhan University, ²Department of Thoracic Surgery, Renmin Hospital of Wuhan University, ³Department of Human Anatomy, Histology and Embryology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, ⁴Department of Immunology, School of Basic Medical Sciences, Wuhan University, ⁵Department of Gastroenterology, Central Hospital of Wuhan, ⁶Department of Transfusion, Zhongnan Hospital of Wuhan University

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue

Guang Lei*¹, Haiyan Yang*¹, Ting Hong², Xiangyu Zhang¹, Nong Yang¹, Yongchang Zhang¹

¹Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, ²Hunan ClinicaI Research Center in Gynecologic Cancer, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University

Patient-derived Heterogeneous Xenograft Model of Pancreatic Cancer Using Zebrafish Larvae as Hosts for Comparative Drug Assessment

Lei Wang*¹, Huan Chen*^2,3, Fei Fei*¹, Xianfeng He^2,3, Shaoyang Sun¹, Kunpeng Lv¹, Bo Yu^2,3, Jiang Long^2,4,5,6, Xu Wang¹

¹Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Fudan University, ²National Human Genetic Resources Sharing Service Platform (2005DKA21300), ³Fudan University Shanghai Cancer Center, ⁴Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, ⁵Department of Oncology, Shanghai Medical College, Fudan University, ⁶Pancreatic Cancer Institute, Fudan University

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Ayman J. Oweida¹, Shilpa Bhatia¹, Benjamin Van Court¹, Laurel Darragh¹, Natalie Serkova^1,2,3, Sana D. Karam¹

¹Department of Radiation Oncology, University of Colorado Denver - Anschutz Medical Campus, ²Department of Anesthesiology, University of Colorado Denver - Anschutz Medical Campus, ³Division of Radiology, University of Colorado Denver - Anschutz Medical Campus

A Practical Guide for the Production and PET/CT Imaging of ⁶⁸Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice

Else A. Aalbersberg¹, Martine M. Geluk-Jonker¹, Thirumaraichelvi Young-Mylvaganan¹, Linda J. de Wit-van der Veen¹, Marcel P. M. Stokkel¹

¹Department of Nuclear Medicine, Netherlands Cancer Institute

Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish

Vadim Le Joncour¹, Sinem Karaman^1,2, Pirjo Maarit Laakkonen^1,3

¹Research Programs Unit, Translational Cancer Medicine Research Program, University of Helsinki, ²Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, ³Laboratory Animal Center, Helsinki Institute of Life Science (HiLIFE), University of Helsinki

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

Mercedes M. Riley^1,2, Pyay San¹, Edwin Lok¹, Kenneth D. Swanson¹, Eric T. Wong¹

¹Brain Tumor Center and Neuro-Oncology Unit, Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, ²Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Yu Zhang¹, Yupeng Yao¹, Yan Zhang¹

¹MOE Key Laboratory of Gene Function and Regulation, School of Life Sciences, Sun Yat-sen University

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