JoVE Journal

Cancer Research

JoVE Cancer Research includes experimental approaches and methods to understand, detect, treat, and prevent cancer.

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Establishing Cell Lines Overexpressing DR3 to Assess the Apoptotic Response to Anti-mitotic Therapeutics

Xin Wang*¹, Jiamin Zhou*², Chen Qi*¹, Gelin Wang^1,3

¹School of Pharmaceutical Sciences, Tsinghua University, ²Department of Radiology, University of California, San Francisco, ³Beijing Advanced Innovation Center for Structural Biology

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Felipe J. Núñez^1,2, Flor M. Mendez², Maria B. Garcia-Fabiani^1,2, Joaquín Pardo^1,3, Marta Edwards^1,2, Pedro R. Lowenstein^1,2, Maria G. Castro^1,2

¹Department of Neurosurgery, University of Michigan Medical School, ²Department of Cell & Developmental Biology, University of Michigan, ³INIBIOLP, Histology B-Pathology B, School of Medicine, UNLP

Evaluation of the Feasibility, Safety, and Accuracy of an Intraoperative High-intensity Focused Ultrasound Device for Treating Liver Metastases

Aurélien Dupre^1,2, David Melodelima², David Perol³, Yao Chen¹, Jérémy Vincenot², Jean-Yves Chapelon², Michel Rivoire^1,2

¹Department of Surgical Oncology, Centre Léon Bérard, ²Applications des ultrasons à la thérapie (LabTAU), Institut national de la santé et de la recherche médicale (INSERM), Centre Léon Bérard, Université Lyon 1, Université Lyon, ³Biostatistics and Treatment Evaluation Unit, Centre Léon Bérard

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Johannes P.W. Heidbuechel^1,2, Christine E. Engeland^1,3

¹Department of Translational Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), ²Faculty of Biosciences, Heidelberg University, ³Department of Medical Oncology, NCT and Heidelberg University Hospital

Mesenchymal Stem Cell Isolation from Pulp Tissue and Co-Culture with Cancer Cells to Study Their Interactions

Ayşegül Doğan¹, Selami Demirci², Hüseyin Apdik¹, Ezgi Avşar Apdik¹, Fikrettin Şahin¹

¹Genetics and Bioengineering, Yeditepe University, ²National Heart, Lung, and Blood Institute (NHLBI), Sickle Cell Branch, National Institutes of Health (NIH)

Investigation of Genetic Dependencies Using CRISPR-Cas9-based Competition Assays

Anagha Deshpande¹, Bo Rui Chen¹, Luyi Zhao¹, Kelsey Saddoris¹, Mayuri Kerr¹, Nan Zhu², Prashant Mali³, Aniruddha J. Deshpande¹

¹Tumor Initiation and Maintenance Program, Sanford Burnham Prebys Medical Discovery Institute, ²Blood Research Institute, Blood Center of Wisconsin, ³Department of Bioengineering, University of California, San Diego

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

Meenu Kesarwani¹, Zachary Kincaid¹, Mohammad Azam¹

¹Cancer Blood Disease Institute, Divisions of Experimental Hematology and Cancer Pathology, Cincinnati Children's Hospital Medical Center

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Gilbert Gastelum¹, Eric Y. Chang², David Shackleford³, Nicholas Bernthal³, Jeffery Kraut^1,3, Kevin Francis⁴, Victoria Smutko¹, Patrick Frost^1,3

¹Greater Los Angeles Veteran Administration Healthcare System, ²San Diego Veterans Administration Healthcare System, ³University of California, Los Angeles, ⁴Perkin Elmer

Development and Angiographic Use of the Rabbit VX2 Model for Liver Cancer

Ramzy C. Khabbaz^1,2, Yu-Hui Huang^1,2, Alexandra A. Smith³, Kelly D. Garcia¹, R. Peter Lokken¹, Ron C. Gaba¹

¹Department of Radiology, University of Illinois, ²College of Medicine, University of Illinois, ³Department of Biological Resources Laboratory, University of Illinois

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay

Yukitomo Arao¹, Kenneth S. Korach¹

¹Reproductive Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health (NIH)

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube (SWCNT)-delivered MALAT1 Antisense Oligos

Jianhong Lin*^1,2, Yi Hu*¹, Jian-Jun Zhao¹

¹Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, ²Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School

A Spheroid Killing Assay by CAR T Cells

Pierre Dillard¹, Hakan Köksal¹, Else-Marit Inderberg¹, Sebastien Wälchli¹

¹Department of Cellular Therapy, Department of Oncology, Oslo University Hospital-Radiumhospitalet

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Farid N. Faruqu*¹, Lizhou Xu*¹, Khuloud T. Al-Jamal¹

¹Institute of Pharmaceutical Science, King's College London

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia

Alexander R. Fuchs¹, Melanie Märklin¹, Jonas S. Heitmann¹, Stefan Futterknecht¹, Michael Haap², Stefan Wirths¹, Hans-Georg Kopp¹, Clemens Hinterleitner¹, Daniela Dörfel¹, Martin R. Müller¹

¹Dept. of Hematology, Oncology and Immunology, University of Tübingen, ²Dept. of Endocrinology, Diabetology, Clinical Pathology and Metabolism, University of Tübingen

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Andreas Agathangelidis*¹, Lesley Ann Sutton*^2,3, Anastasia Hadzidimitriou¹, Cristina Tresoldi⁴, Anton W. Langerak⁵, Chrysoula Belessi⁶, Frederic Davi⁷, Richard Rosenquist^2,3, Kostas Stamatopoulos^1,2, Paolo Ghia⁸

¹Institute of Applied Biosciences, Centre for Research and Technology Hellas, ²Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, ³Department of Molecular Medicine and Surgery, Karolinska Institutet, ⁴Division of Immunology, Transplantation and Infectious, IRCCS San Raffaele Scientific Institute, ⁵Department of Immunology, Laboratory for Medical Immunology, Erasmus University Medical Center, ⁶Hematology Department, Nikea General Hospital, ⁷Assistance publique - Hôpitaux de Paris (AP-HP), Hopital Pitié-Salpêtrière, Department of Hematology, and UPMC University Paris 06, UMRS 1138, ⁸Division of Experimental Oncology, IRCCS Istituto Scientifico San Raffaele and Università Vita-Salute San Raffaele

Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches

Yavuz F. Yazicioglu^1,2, Halil I. Aksoylar^1,2, Rinku Pal^1,2, Nikolaos Patsoukis^1,2, Vassiliki A. Boussiotis^1,2

¹Division of Hematology-Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, ²Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School

Assessment of the Metabolic Profile of Primary Leukemia Cells

Katerina Hlozková¹, Julia Starková¹

¹CLIP - Childhood Leukemia Investigation Prague, Second Faculty of Medicine, Laboratory of Molecular Genetics, Charles University, Prague

Morphology-Based Distinction Between Healthy and Pathological Cells Utilizing Fourier Transforms and Self-Organizing Maps

Fabian L. Kriegel^1,2, Ralf Köhler², Jannike Bayat-Sarmadi², Simon Bayerl³, Anja E. Hauser^2,3, Raluca Niesner², Andreas Luch*¹, Zoltan Cseresnyes*⁴

¹Department of Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), ²Deutsches Rheuma-Forschungszentrum (DRFZ) Berlin, a Leibniz Institute, ³Charité Universitätsmedizin Berlin, ⁴Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute

Analysis of Cancer Cell Invasion and Anti-metastatic Drug Screening Using Hydrogel Micro-chamber Array (HMCA)-based Plates

Orit Ravid-Hermesh¹, Naomi Zurgil¹, Yana Shafran¹, Elena Afrimzon¹, Maria Sobolev¹, Yaron Hakuk¹, Zehavit Bar-On Eizig¹, Mordechai Deutsch¹

¹Physics Department, Bar-Ilan University

A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells

Gray Kueberuwa¹, Weiming Zheng¹, Milena Kalaitsidou¹, David E. Gilham^1,2, Robert E. Hawkins¹

¹Manchester Cancer Research Centre Building, Department Cancer Sciences, University of Manchester, ²Celyad

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Xin Feng¹, Shaofei Wang¹, Quewang Liu¹, Han Li², Jiamei Liu², Cheng Xu², Weifeng Yang², Yayun Shu², Weiwei Zheng¹, Bingxin Yu³, Mingran Qi⁴, Wenyang Zhou¹, Fengfeng Zhou¹

¹College of Computer Science and Technology, and Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, ²College of Software, Jilin University, ³Ultrasonography Department, China-Japan Union Hospital of Jilin University, ⁴Department of Pathogenobiology, College of Basic Medical Science, Jilin University

Immunophenotyping of Orthotopic Homograft (Syngeneic) of Murine Primary KPC Pancreatic Ductal Adenocarcinoma by Flow Cytometry

Xiaoyu An*^1,2, Xuesong Ouyang*¹, Hui Zhang¹, Tingting Li¹, Yu-yang Huang¹, Zhiyuan Li¹, Demin Zhou², Qi-Xang Li^1,2

¹Crown Bioscience Inc., ²State Key Laboratory of Natural and Biomimetic Drugs, Peking University

Phospho Flow Cytometry with Fluorescent Cell Barcoding for Single Cell Signaling Analysis and Biomarker Discovery

Sigrid S. Skånland^1,2

¹Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, ²K. G. Jebsen Centre for B cell malignancies and K. G. Jebsen Centre for Cancer Immunotherapy, University of Oslo

Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients

Marius Ilié^1,2,3, Mélanie Ngo-Mai¹, Elodie Long-Mira^1,2, Sandra Lassalle^1,2, Catherine Butori¹, Coraline Bence¹, Marame Hamila¹, Véronique Hofman^1,2,3, Paul Hofman^1,2,3

¹Laboratory of Clinical and Experimental Pathology, Pasteur Hospital, Hospital University Federation OncoAge, Université Côte d’Azur, ²Institute for Research on Cancer and Aging in Nice (Inserm U1081 and CNRS 7284), Université Côte d’Azur, ³Hospital-Integrated Biobank (BB-0033-00025), Pasteur Hospital, Université Côte d’Azur

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