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全身和局部给药治疗的中枢神经系统疾病的啮齿动物模型
JoVE Journal
Neuroscience
This content is Free Access.
JoVE Journal
Neuroscience
Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
Please note that all translations are automatically generated.
Click here for the English version.
全身和局部给药治疗的中枢神经系统疾病的啮齿动物模型
DOI:
10.3791/1992-v
•
11:51 min
•
August 16, 2010
•
Laura Serwer
,
Rintaro Hashizume
,
Tomoko Ozawa
,
C. David James
1
Department of Neurological Surgery
,
University of California, San Francisco – UCSF
Chapters
00:04
Title
00:31
Introduction
01:08
Tail Vein Injection
02:49
IP Injection
04:01
Oral Gavage
05:21
Acute Convection-Enhanced Delivery
09:40
In vivo Imaging
10:07
Representative Results
11:21
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
彻底在中枢神经系统的药物,临床前试验,往往涉及的评估和比较药物体内分布与管理的具体路线协会。在这里,三个系统性交付的常用方法(静脉,腹腔,口腔),以及为本地传递方法(对流增强交付)在小鼠体内证明。
Tags
Systemic Drug Delivery
Local Drug Delivery
Central Nervous System Diseases
Rodent Models
Therapeutic Efficacy
Routes Of Administration
Agent Biodistribution
Systemic Delivery Approaches
Local Delivery Methods
Intravenous Injection
Intraperitoneal Injection
Oral Gavage
Convection-enhanced Delivery (CED)
Fluorescently-labeled Compounds
In Vivo Imaging
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