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全身和局部给药治疗的中枢神经系统疾病的啮齿动物模型
JoVE Journal
Neuroscience
This content is Free Access.
JoVE Journal Neuroscience
Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
DOI:

11:51 min

August 16, 2010

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Chapters

  • 00:04Title
  • 00:31Introduction
  • 01:08Tail Vein Injection
  • 02:49IP Injection
  • 04:01Oral Gavage
  • 05:21Acute Convection-Enhanced Delivery
  • 09:40In vivo Imaging
  • 10:07Representative Results
  • 11:21Conclusion

Summary

Automatic Translation

彻底在中枢神经系统的药物,临床前试验,往往涉及的评估和比较药物体内分布与管理的具体路线协会。在这里,三个系统性交付的常用方法(静脉,腹腔,口腔),以及为本地传递方法(对流增强交付)在小鼠体内证明。

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