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A Reverse Genetic Approach to Test Functional Redundancy During Embryogenesis
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A Reverse Genetic Approach to Test Functional Redundancy During Embryogenesis

Article DOI: 10.3791/2020 • 07:00 min • August 11th, 2010
August 11th, 2010 •
1, 1, 1, 1
1Department of Surgery, Weill Cornell Medical College of Cornell University

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Summary
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Gene function can be obscured in loss-of-function experiments if there is compensation by another gene. The zebrafish model provides a relatively high-throughput means to reveal such functional redundancy in living embryos.

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Reverse Genetic Approach Functional Redundancy Embryogenesis Loss-of-function Experiments Targeted Mutagenesis Knockout Zebrafish Model Gene-specific Antisense Morpholinos MRNA Translation Inhibition Splicing Inhibition Knockdown Gene Compensation Gene Families Sister Genes Co-expression High-throughput Testing Genetic Interaction Sub-threshold Levels GATA Transcription Factor
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