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压力控制通气诱导小鼠急性肺损伤
JoVE Journal
Medicine
This content is Free Access.
JoVE Journal
Medicine
Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice
Please note that all translations are automatically generated.
Click here for the English version.
压力控制通气诱导小鼠急性肺损伤
DOI:
10.3791/2525-v
•
07:55 min
•
May 05, 2011
•
Michael Koeppen
,
Tobias Eckle
,
Holger K. Eltzschig
1
Department of Anesthesiology
,
University of Colorado
Chapters
00:05
Title
01:10
Surgical Preparation
02:53
Ventilator-induced Lung Injury
04:52
Sample Collection
07:17
Measurement of Lung Injury
07:36
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
一个呼吸机诱导肺损伤的小鼠模型是一个重要的工具,研究急性肺损伤<em>在体内</em>。在这里,我们报告一件容易的适用<em>原位</em>模型使用高压机械通气诱发急性肺衰竭的急性肺伤害。
Tags
Pressure Controlled Ventilation
Acute Lung Injury
ALI
Mice
Murine Models
Mechanical Ventilation
Genetic Targets
Pharmacological Targets
Pulmonary Edema
Pulmonary Gas Exchange
Ventilator-induced Lung Injury
C57BL/6 Mice
Tracheotomy
Inspiratory Peak Pressure
Outcome Parameters
Wet-to-dry Ratio
Bronchoalveolar Fluid Albumin Content
Myeloperoxidase Content
Pulmonary Inflammation
Treatment Groups
Genotypes
Gene-targeted Deletion
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