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1Department of Molecular and Medical Pharmacology, David Geffen School of Medicine,University of California at Los Angeles, 2Crump Institute for Molecular Imaging, David Geffen School of Medicine,University of California at Los Angeles, 3California NanoSystems Institute,University of California at Los Angeles, 4Nuclear Medicine, PET Center, Shanghai Medical Collegea,Fudan University, 5Electronics and Information Engineering, College of Electronics and Information Engineering,Wuhan Textile University
Chapters
- 00:05Title
- 01:51Preparation for [18F]SFB Synthesis
- 03:03[18F]SFB Synthesis
- 04:44Preparation of Solid Phase Extraction (SPE)-purified [18F]SFB
- 07:24Representative Results for the Microwave-assisted One-pot Synthesis of [18F]SFB
- 08:10Conclusion
एक सतही, एक पॉट संश्लेषण एन succinimidyl चार - [<sup18></supFluorobenzoate> एफ] ([<sup18></sup> फा] SFB) एक गैर जलीय radiochemical तीन कदम प्रक्रिया के आधार पर विकसित किया गया था. माइक्रोवेव हीटिंग का प्रयोग, पूरी प्रक्रिया में कम से कम 30 मिनट, या प्रारंभिक HPLC द्वारा आगे शुद्धि के साथ 60 मिनट में पूरा किया जा सकता है. क्षय सही radiochemical पैदावार (RCYs) 35-5% (n> 30) थे.
Tags
Microwave-assistedOne-pot SynthesisN-succinimidyl-4-[18F]fluorobenzoate[18F]SFBBiomoleculesPeptidesProteinsAntibodiesEngineered FragmentsTherapeuticsMolecular Imaging AgentsPositron-emitting RadioisotopesCu-64Ga-68F-18Targeted ImagingPhysiological ProcessesPathological ProcessesSynthesisExploration18F-labeled BiomoleculesDirect 18F-labelingOrganic SolventExtreme PHHigh TemperatureRadiolabeled Prosthetic GroupsMethod Of ChoiceBolton-Hunter Type ReagentPrimary Amino GroupsIn Vivo StabilityRadiolabeling YieldPET Tracers
