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JoVE Journal
Biology

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激光烧蚀斑马鱼Pronephros研究肾小管上皮再生
 
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激光烧蚀斑马鱼Pronephros研究肾小管上皮再生

Article DOI: 10.3791/2845
August 29th, 2011

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Summary August 29th, 2011

Please note that all translations are automatically generated.

Click here for the English version.

在人类急性肾损伤(AKI)是临床常见的问题,造成损害的上皮细胞,包括肾肾,AKI的是与高死亡率的50-70%1。上皮细胞破坏,肾有再生能力有限,但指导这一现象的机制和限制,仍然知之甚少。在这个视频文章中,我们描述了我们的技术在斑马鱼胚胎的肾脏,肾肾细胞有针对性的激光烧蚀或pronephros。我们的新方法,可以用来补充AKI的肾毒性引起的模型和肾肾上皮再生的细胞和分子变化,获得高分辨率的认识。

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