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5/6th联合切除术,高盐饮食和一氧化氮合酶抑制剂诱导Lewis大鼠慢性肾脏病
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Medicine
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JoVE Journal
Medicine
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Please note that all translations are automatically generated.
Click here for the English version.
5/6th联合切除术,高盐饮食和一氧化氮合酶抑制剂诱导Lewis大鼠慢性肾脏病
DOI:
10.3791/50398-v
•
08:50 min
•
July 03, 2013
•
Arianne van Koppen
,
Marianne C. Verhaar
,
Lennart G. Bongartz
,
Jaap A. Joles
1
Department of Nephrology & Hypertension
,
University Medical Center Utrecht
Chapters
00:05
Title
01:15
Preparation for Surgery
05:13
Left Side Subtotal Nephrectomy
06:12
Representative Nephrectomy Results
08:23
Conclusion
Summary
Automatic Translation
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Automatic Translation
两阶段方法建立Lewis大鼠慢性肾脏病(CKD),通过手术取出肾质量5/6th描述。结合的外科手术过程中,一氧化氮合酶抑制和高盐饮食导致类似人类的CKD的模型,允许因果机制的研究和发展新的治疗干预。
Tags
5/6th Nephrectomy
Chronic Kidney Disease
Lewis Rat
High Salt Diet
Nitric Oxide Synthase Inhibition
Glomerular Filtration Rate
Renal Plasma Flow
Hypertension
Proteinuria
Uremia
Tubulo-interstitial Damage
Glomerulosclerosis
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