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浸润性膀胱移行细胞癌中的完整的人MUC1转基因小鼠免疫诱导免疫治疗发展模型
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JoVE Journal Medicine
Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
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浸润性膀胱移行细胞癌中的完整的人MUC1转基因小鼠免疫诱导免疫治疗发展模型

DOI:
10.3791/50868-v

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11:02 min

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October 30, 2013

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, , , , , , ,
1Department of Internal Medicine, Division of Hematology and Oncology,University of California, Davis, 2Comparative Pathology Laboratory, UC Davis School of Veterinary Medicine,University of California, Davis, 3Merck Serono Research,Merck KGaA, Darmstadt, Germany

Chapters

  • 00:05Title
  • 01:43Bladder Cancer Induction and Vaccination Treatments
  • 02:49Monitoring and Sample Collection
  • 04:11Multiplex Fluorometric Microbead Immunoassay
  • 06:37IFN-γ/IL-4 ELISpot Preparation and Analysis
  • 08:07Representative Transitional Cell Bladder Carcinoma Induction Results
  • 10:39Conclusion

Summary

Automatic Translation

Automatic Translation

的N-丁基-N-（4 - 羟丁基）亚硝胺的人粘蛋白1（MUC1）测试的目的MUC1基因定向免疫治疗的转基因小鼠中诱导的膀胱癌模型的开发。施用MUC1的目标肽疫苗后，MUC1的细胞毒性T淋巴细胞反应证实，通过测定血清中的细胞因子水平和T细胞的比活性。

Tags

Bladder CancerTransitional Cell CarcinomaSquamous Cell CarcinomaMUC1 TransgenicN-butyl-N-(4-hydroxybutyl)nitrosamineCytokinesImmunotherapyPeptide VaccineT-cell Response

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