Journal
/
Medicine
/
Induktion af Invasive Transitional Cell blærecarcinom i Immune intakt humant MUC1 transgene mus: En model for immunterapi Development
JoVE Journal
Medicine
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Medicine
Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Induktion af Invasive Transitional Cell blærecarcinom i Immune intakt humant MUC1 transgene mus: En model for immunterapi Development

DOI:
10.3791/50868-v

•

11:02 min

•

October 30, 2013

•

, , , , , , ,
1Department of Internal Medicine, Division of Hematology and Oncology,University of California, Davis, 2Comparative Pathology Laboratory, UC Davis School of Veterinary Medicine,University of California, Davis, 3Merck Serono Research,Merck KGaA, Darmstadt, Germany

Chapters

  • 00:05Title
  • 01:43Bladder Cancer Induction and Vaccination Treatments
  • 02:49Monitoring and Sample Collection
  • 04:11Multiplex Fluorometric Microbead Immunoassay
  • 06:37IFN-γ/IL-4 ELISpot Preparation and Analysis
  • 08:07Representative Transitional Cell Bladder Carcinoma Induction Results
  • 10:39Conclusion

Summary

Automatic Translation

Automatic Translation

En N-butyl-N-(4-hydroxybutyl) nitrosamin-induceret blærekræft model blev udviklet i human mucin 1 (MUC1) transgene mus med henblik på prøvning MUC1-rettet immunterapi. Efter indgivelse af et MUC1 målrettet peptidvaccine, blev en cytotoksisk T-lymfocyt respons på MUC1 bekræftet ved måling af serum cytokinniveauer og T-celle specifik aktivitet.

Tags

Bladder CancerTransitional Cell CarcinomaSquamous Cell CarcinomaMUC1 TransgenicN-butyl-N-(4-hydroxybutyl)nitrosamineCytokinesImmunotherapyPeptide VaccineT-cell Response

Article

Embed

ADD TO PLAYLIST

Usage Statistics

Related Videos

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma

Protokol for Long Duration Whole Body Hypertermi i mus

The Use of Cystometry in Small Rodents: A Study of Bladder Chemosensation

Generering af Subkutan og Intrahepatisk Menneskelige hepatocellulært carcinom xenotransplantater i immunsvækkede mus

Urinblæren Udspilning Evoked Visceromotor Responses som en model for blæresmerter i mus

Facial Nerve aksotomi i mus: en model til at studere motoneuron Reaktion på Skade

Induktion af accelereret åreforkalkning i Mus: Den "Wire-Skade" Model

Teknik, minimalt Invasive tværgående aorta konstriktion i mus til induktion af venstre ventrikel hypertrofi

En minimalt invasiv Model til at analysere Endochondral fraktur Healing i mus Under standardiserede biomekaniske forhold

Read Article