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Induksjon av Invasive Transitional Cell blære carcinoma in Immune Intakt Menneskelige MUC1 transgene mus: En modell for Immunterapi Development
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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Induksjon av Invasive Transitional Cell blære carcinoma in Immune Intakt Menneskelige MUC1 transgene mus: En modell for Immunterapi Development

DOI:
10.3791/50868-v

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11:02 min

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October 30, 2013

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, , , , , , ,
1Department of Internal Medicine, Division of Hematology and Oncology,University of California, Davis, 2Comparative Pathology Laboratory, UC Davis School of Veterinary Medicine,University of California, Davis, 3Merck Serono Research,Merck KGaA, Darmstadt, Germany

Chapters

  • 00:05Title
  • 01:43Bladder Cancer Induction and Vaccination Treatments
  • 02:49Monitoring and Sample Collection
  • 04:11Multiplex Fluorometric Microbead Immunoassay
  • 06:37IFN-γ/IL-4 ELISpot Preparation and Analysis
  • 08:07Representative Transitional Cell Bladder Carcinoma Induction Results
  • 10:39Conclusion

Summary

Automatic Translation

Automatic Translation

Et N-butyl-N-(4-hydroksybutyl) nitrosamin-indusert blærekreft modell ble utviklet i human mucin 1 (MUC1) transgene mus for å teste MUC1-rettet immunterapi. Etter administrering av en MUC1-målrettet peptid vaksine, ble en cytotoksisk T-lymfocytt respons på MUC1 bekreftet ved å måle serum cytokin nivåer og T-celle spesifikke aktivitet.

Tags

Bladder CancerTransitional Cell CarcinomaSquamous Cell CarcinomaMUC1 TransgenicN-butyl-N-(4-hydroxybutyl)nitrosamineCytokinesImmunotherapyPeptide VaccineT-cell Response

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