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Rapid Generation of Amyloid from Native Proteins In vitro
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Rapid Generation of Amyloid from Native Proteins In vitro

Article DOI: 10.3791/50869-v 05:48 min December 5th, 2013
December 5th, 2013



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Click here for the English version.

Proteins can either adopt a native structure or misfold into insoluble amyloid. Conditions that favor the misfolding pathway lead to the formation of different types of amyloid fibrils. The methods described here allow rapid conversion of native proteins into amyloid in vitro.


Amyloid Proteins Native Structures Beta-sheet Fibrils Cellular Processes Patient Tissues Nucleic Acids Glycosaminoglycans (GAGs) Insoluble Precipitates Misfold Soluble Amyloid Precursor In Vitro
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