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Amid Kobling Reaktion for syntesen af ​​bispyridin-baserede ligander og deres kompleksdannelse til Platinum som bicycliske anticancerlægemidler
JoVE Journal
Chemistry
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JoVE Journal Chemistry
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
DOI:

07:20 min

May 28, 2014

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Chapters

  • 00:05Title
  • 01:22Synthesis of the N,N’-(alkane-1,n-diyl)diisonicotinamide
  • 02:32Purification of the Ligands
  • 03:23Synthesis and Purification of the Dinuclear Platinum Complexes
  • 05:09Results: Characterization of Bispyridine Ligands and Dinuclear Platinum Complexes
  • 06:54Conclusion

Summary

Automatic Translation

Denne protokol beskriver anvendelsen af ​​amidkobling reaktioner isonikotinsyre og diaminoalkaner til dannelse brodannende ligander egnede til anvendelse i syntesen af ​​multinucleare platinkomplekser, der kombinerer aspekter af anticancerlægemidler BBR3464 og picoplatin.

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