Journal
/
/
Induksjon av murine tarmbetennelse etter adoptiv overføring av Effector CD4<sup> +</sup> CD45RB<sup> Høy</sup> T-celler i immundefekte mus
JoVE Journal
Immunology and Infection
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Immunology and Infection
Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Induksjon av murine tarmbetennelse etter adoptiv overføring av Effector CD4<sup> +</sup> CD45RB<sup> Høy</sup> T-celler i immundefekte mus

16,114 Views

08:37 min

April 21, 2015

DOI:

08:37 min
April 21, 2015

27 Views
, ,

Summary

Automatically generated

Here, we present a protocol to induce colonic inflammation in mice by adoptive transfer of syngeneic CD4+CD45RBhigh T cells into T and B cell deficient recipients. Clinical and histopathological features mimic human inflammatory bowel diseases. This method allows the study of the initiation of colonic inflammation and progression of disease.

Read Article