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JoVE Journal
Biology

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Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis
 

Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis

Article DOI: 10.3791/52824
July 3rd, 2015

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Summary July 3rd, 2015

Receptor trafficking modulates signaling and cell responsiveness to ligands and is, itself, responsive to cell conditions, including ligand-induced signaling. Here, we describe a powerful and flexible technique for quantitatively assessing drug-induced receptor trafficking using immunolabeling and colocalizational analysis.

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