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Un directa, Protocolo Guanidinylation Etapa Temprana para la Síntesis de complejos productos naturales que contiene aminoguanidina-
JoVE Journal
Chemistry
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JoVE Journal Chemistry
A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
DOI:

09:04 min

September 09, 2016

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Chapters

  • 00:05Title
  • 00:41Synthesis of Carbamate from Di-Boc Agmatine Isocyanate and 2,4-DibromoHGAL
  • 03:12Purification of Carbamate
  • 05:53Synthesis and Isolation of Clavatadine A
  • 07:25Results: Synthesis and Characterization of Clavatadine A and Its Precursors
  • 08:19Conclusion

Summary

Automatic Translation

Here, we present a protocol for direct, early stage guanidinylation that enables rapid total synthesis of aminoguanidine-containing small organic molecules. An advanced synthetic intermediate used in the synthesis of a blood coagulation factor XIa inhibitor was prepared using this protocol.

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