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体内
在肿瘤微环境中 pH 值、
p
O
2
、氧化还原状态、磷酸盐和谷胱甘肽浓度的 EPR 评价
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JoVE Journal
Cancer Research
In Vivo
EPR Assessment of pH,
p
O
2
, Redox Status, and Concentrations of Phosphate and Glutathione in the Tumor Microenvironment
Please note that all translations are automatically generated.
Click here for the English version.
体内
在肿瘤微环境中 pH 值、
p
O
2
、氧化还原状态、磷酸盐和谷胱甘肽浓度的 EPR 评价
DOI:
10.3791/56624-v
•
10:46 min
•
March 16, 2018
•
Andrey A. Bobko
2
,
Timothy D. Eubank
3
,
Benoit Driesschaert
2
,
Valery V. Khramtsov
2
1
In Vivo Multifunctional Magnetic Resonance center, Robert C. Byrd Health Sciences Center
,
West Virginia University
,
2
Department of Biochemistry
,
West Virginia University School of Medicine
,
3
Department of Microbiology, Immunology & Cell Biology
,
West Virginia University School of Medicine
Chapters
00:04
Title
01:20
Probe Synthesis and Calibration
05:42
Probe Delivery for
In Vivo
Functional Measurements
07:18
In Vivo
Functional Measurements
08:09
Results: EPR Assessment in the Tumor Microenvironment
10:04
Conclusion
Summary
Automatic Translation
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Automatic Translation
利用可溶性基团和三苯三苯探针对低场 (L 波段, 1.2 GHz) 电子顺磁共振进行了分析, 以评估乳腺癌小鼠模型中肿瘤微环境中生理上的重要参数。
Tags
In Vivo EPR
Tumor Microenvironment
Physiological Parameters
Oxygen Tension
Redox Status
Phosphate
Glutathione
Noninvasive Assessment
Paramagnetic Probes
Oxygen-sensitive Probe
PH And Redox Probe
Calibration
EPR Spectroscopy
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