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利用瞬态受体电位辣椒1型 Ultrapotent 激动剂建立单纯小纤维神经病变的小鼠模型
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Neuroscience
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JoVE Journal Neuroscience
Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
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利用瞬态受体电位辣椒1型 Ultrapotent 激动剂建立单纯小纤维神经病变的小鼠模型

DOI:
10.3791/56651-v

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09:39 min

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February 13, 2018

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, ,
1Department of Anatomy, School of Medicine, College of Medicine,Kaohsiung Medical University, 2Department of Medical Research,Kaohsiung Medical University Hospital, 3Department of Medical Research, Ultrastructural Laboratory,Kaohsiung Medical University Hospital

Chapters

  • 00:04Title
  • 00:46Establishment of Resiniferatoxin (RTX) Neuropathy
  • 01:45Behavioral Testing: Hot Plate and von Frey Hair
  • 03:55Skin Biopsy Preparation and Evaluation of IENFs Innervation
  • 06:18DRG Section Preparation and Evaluation of Injured Small-Diameter Neurons
  • 07:25Results: Comparing RTX Doses
  • 08:35Conclusion

Summary

Automatic Translation

Automatic Translation

本研究建立了树酯毒素 (RTX) 纯小纤维神经病变的实验模型。独特剂量的 RTX (50 µg/千克) 是最佳的发展一个小纤维神经病变模型, 模仿病人的特点, 并可以帮助调查的伤害性分子意义下的神经病理性疼痛。

Tags

Mouse ModelSmall Fiber NeuropathyTransient Receptor Potential Vanilloid Type 1ResiniferatoxinRTXHot Plate TestVon Frey Hair FilamentsSensory NeuropathyNeurotoxin Delivery

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