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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
JoVE Journal
Neuroscience
This content is Free Access.
JoVE Journal Neuroscience
Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
DOI:

07:16 min

August 16, 2018

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Chapters

  • 00:04Title
  • 00:54Receptor Expression and Recordings in Xenopus Oocytes
  • 02:16Electrophysiological Recordings in Rat Brain Slices
  • 05:39Results: A GABAA NAM Reduces Paired-pulse Inhibition in Hippocampal Slices
  • 06:49Conclusion

Summary

Automatic Translation

Here, we present protocols to discover compounds active at GABAA receptors, from the binding to the physiology and pharmacology.

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