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Estabelecer um modelo de Mouse de uma neuropatia de pura fibra pequena com o ultrapotente agonista do Receptor transitório potencial Vanilloid tipo 1
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
DOI:

09:39 min

February 13, 2018

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Chapters

  • 00:04Title
  • 00:46Establishment of Resiniferatoxin (RTX) Neuropathy
  • 01:45Behavioral Testing: Hot Plate and von Frey Hair
  • 03:55Skin Biopsy Preparation and Evaluation of IENFs Innervation
  • 06:18DRG Section Preparation and Evaluation of Injured Small-Diameter Neurons
  • 07:25Results: Comparing RTX Doses
  • 08:35Conclusion

Summary

Automatic Translation

Este estudo estabelece um modelo experimental de neuropatia de pura fibra pequena com reductase (RTX). Uma única dose de RTX (50 µ g/kg) é ideal para o desenvolvimento de um modelo de neuropatia de pequenas fibras que imita as características do pacientes e pode ajudar a investigar o significado molecular nociceptivo subjacente a dor neuropática.

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