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En musemodel af ortopædisk kirurgi til at studere postoperativ kognitiv dysfunktion og vævsregeneration
JoVE Journal
Medicine
This content is Free Access.
JoVE Journal Medicine
A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
DOI:

08:17 min

February 27, 2018

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Chapters

  • 00:05Title
  • 00:50Preoperative Setup for Parabiosis and Orthopedic Surgery
  • 01:48Parabiosis Surgery
  • 04:02Tibial Fracture Surgery
  • 06:23Results: Parabiosis Surgery Leads to Rejuvenation of Fracture Healing, Blood-sharing, and Donor-cell Engraftment
  • 07:36Conclusion

Summary

Automatic Translation

Denne protokol beskriver en musemodel af ortopædisk kirurgi, der er blevet brugt til at studere mekanismer af postoperative neuroinflammation og adfærdsmæssige ændringer, og når det kombineres med parabiosis, at studere vævsregeneration under aldring.

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