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Bioengineering
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建立一种结构逼真的心肌细胞的有限元几何模型研究蜂窝结构在心肌系统生物学中的作用
JoVE Journal
Bioengineering
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JoVE Journal
Bioengineering
Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology
Please note that all translations are automatically generated.
Click here for the English version.
建立一种结构逼真的心肌细胞的有限元几何模型研究蜂窝结构在心肌系统生物学中的作用
DOI:
10.3791/56817-v
•
08:54 min
•
April 18, 2018
•
Vijay Rajagopal
2,3
,
Gregory Bass
3
,
Shouryadipta Ghosh
2,3
,
Hilary Hunt
4
,
Cameron Walker
,
Eric Hanssen
,
Edmund Crampin
3,4,7,8
,
Christian Soeller
1
Cell Structure and Mechanobiology Group
,
University of Melbourne
,
2
Systems Biology Laboratory, Melbourne School of Engineering
,
University of Melbourne
,
3
Department of Biomedical Engineering
,
University of Melbourne
,
4
School of Mathematics and Statistics, Faculty of Science
,
University of Melbourne
,
5
Department of Engineering Science
,
University of Auckland
,
6
Advanced Microscopy Facility, Bio21 Molecular Science and Biotechnology Institute
,
University of Melbourne
,
7
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology
,
University of Melbourne
,
8
School of Medicine, Faculty of Medicine, Dentistry and Health Sciences
,
University of Melbourne
,
9
Living Systems Institute
,
University of Exeter
Chapters
00:04
Title
01:19
Segment Myofibrils and Mitochondria Regions from the EM 3D Image Dataset
03:05
Create a Finite Element Mesh from the Segmented Components
04:36
Mathematically Map the Spatially Varying Density of Ion-channels of Interest onto the Finite Element Mesh
06:51
Results: A Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte
08:13
Conclusion
Summary
Automatic Translation
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Automatic Translation
该协议概述了一种新的方法, 以建立一个空间详细的有限元模型的细胞内体系结构的电子显微镜和共焦显微图像。通过对钙信号和生物能学的案例研究, 证明了这个空间细节模型的威力。
Tags
Finite Element Model
Cardiomyocyte
Cellular Architecture
Cardiac Cell Systems Biology
Electron Microscopy
Confocal Microscopy
IMOD
3D Reconstruction
Mitochondria
Contour
Object Modeling
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