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High-throughput identificatie van synergetische Drug combinaties door de overlapping2 methode
JoVE Journal
Genetics
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JoVE Journal Genetics
High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method
DOI:

07:51 min

May 21, 2018

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Chapters

  • 00:04Title
  • 00:49Identifying Synergy Prediction Mutants from Chemical-genetics Dataset by the Overlap2 Method
  • 01:17Validation of Predicted Synergistic Interactions
  • 04:52High-throughput Screen with Synergy Prediction Mutants to Identify the Novel Synergistic Pairs
  • 05:21Results: Use of Checkerboard Assay to Identify and Validate Synergistic Drug Molecules
  • 07:05Conclusion

Summary

Automatic Translation

Synergetische drug combinaties zijn moeilijk en tijdrovend te identificeren empirisch. Hier beschrijven we een methode voor het vaststellen en valideren van synergetische kleine moleculen.

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