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En flöde flödescytometri-baserad analys identifiera föreningar som stör bindningen av Fluorescently-märkta CXC Chemokine Ligand 12 till CXC Chemokine Receptor 4
JoVE Journal
Biology
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JoVE Journal Biology
A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4
DOI:

06:56 min

March 10, 2018

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Chapters

  • 00:04Title
  • 00:54Competition Binding Assay
  • 03:00Analysis of the Samples by Flow Cytometry
  • 05:35Results: Evaluation and Analysis of Active and Inactive Compounds in the Competition Binding Assay
  • 06:35Conclusion

Summary

Automatic Translation

Ett flöde flödescytometri-baserade cellulära bindande analys beskrivs som används främst som en screeningmetod för att identifiera substanser som hämmar bindningen av en fluorescently märkt CXC chemokine ligand 12 (CXCL12) till CXC chemokine receptorn 4 (CXCR4).

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